Frontotemporal dementia (FTD): differential diagnosis

Evidence-based neurology checklist on frontotemporal dementia (ftd): differential diagnosis: Clinical differentials Primary progressive aphasia (PPA) Vascular dementia Alzheimer’s disease (AD) Depression Frontotemporal brain sagging syndrome (FBSS) Cerebrospinal fluid-venous fistula (CSF-venous…

Clinical differentials

  • Primary progressive aphasia (PPA)
  • Vascular dementia
  • Alzheimer’s disease (AD)
  • Depression
  • Frontotemporal brain sagging syndrome (FBSS)
  • Cerebrospinal fluid-venous fistula (CSF-venous fistula)
  • Primary psychiatric disorders

Differentiating features supporting FTD

Differentiating features of temporal (tv-FTD) from frontal variant FTD (fv-FTD)

Differentials of primary progressive aphasia (PPA)

References

  1. Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 2010; 24:375-398.
  2. Kertesz A, Nadkarni N, Davidson W, Thomas AW. The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia. J Int Neuropsychol Soc 2000; 6:460-468.
  3. Mendez MF, Cherrier M, Perryman KM, Pachana N, Miller BL, Cummings JL. Frontotemporal dementia versus Alzheimer's disease: differential cognitive features. Neurology 1996; 47:1189-1194.
  4. Rosen HJ, Hartikainen KM, Jagust W, et al. Utility of clinical criteria in differentiating Frontotemporal lobar degeneration (FTLD) from AD. Neurology 2002; 58:1608-1615.
  5. Wicklund MR, Mokri B, Drubach DA, Boeve BF, Parisi JE, Josephs KA. Frontotemporal brain sagging syndrome: an SIH-like presentation mimicking FTD. Neurology 2011; 76:1377-1382.
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