Folate deficiency syndromes: classification

Evidence-based neurology checklist on folate deficiency syndromes: classification: Central folate deficiency syndromes Stroke Cerebral folate deficiency (CFD) Encephalopathy Mood disorder Psychosis Spinal folate deficiency syndromes Peripheral folate deficiency syndromes

Central folate deficiency syndromes

  • Stroke
  • Cerebral folate deficiency (CFD)
  • Encephalopathy
  • Mood disorder
  • Psychosis

Spinal folate deficiency syndromes

Peripheral folate deficiency syndromes

References

  1. Manzoor M, Runcie J. Folate-responsive neuropathy: report of 10 cases. Br Med J 1976; 1:1176-1178.
  2. Zhao M, Wu G, Li Y, Wang X, Hou FF, Xu X, Qin X, Cai Y. Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers. Neurology 2017; 88:1830-1838.
  3. Zeng R, Xu CH, Xu YN, Wang YL, Wang M. The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis. Public Health Nutr 2015; 18:1514-1521.
  4. Qin X, Li J, Spence JD, Zhang Y, et al. Folic acid therapy reduces the first stroke risk associated with hypercholesterolemia among hypertensive patients. Stroke 2016; 47:2805-2812. 
  5. Huo Y, Li J, Qin X, et al; CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA 2015; 313:1325-1335. 
  6. And 10 more. Subscribe to see the full list

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