Epilepsy remission

Evidence-based neurology checklist on epilepsy remission: Definition of remission 5 years of seizure-freedom The last 2 years should be off medications Proposed re-definition of remission Frequency of achieving remission Predictors of spontaneous remission Predictors of treatment remission…

Definition of remission

  • 5 years of seizure-freedom
  • The last 2 years should be off medications

Proposed re-definition of remission

Frequency of achieving remission

Predictors of spontaneous remission

Predictors of treatment remission

Predictors of failure to achieve remission

References

  1. Kwan P, Sander JW. The natural history of epilepsy: an epidemiological view. JNNP 2004; 75:1376-1381.
  2. Sillanpää M, Schmidt D, Saarinen MM, Shinnar S. Remission in epilepsy: how long is enough? Epilepsia 2017; 58:901-906. 
  3. Shorvon SD, Goodridge DM. Longitudinal cohort studies of the prognosis of epilepsy: contribution the National General Practice Study of Epilepsy and other studies. Brain 2013; 136:3497-3510. 
  4. Giussani G, Canelli V, Bianchi E, et al; EPIRES Group. Long-term prognosis of epilepsy, prognostic patterns and drug resistance: a population-based study. Eur J Neurol 2016; 23:1218-1227. 
  5. Annegers JF, HauserWA, Elveback LR. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979; 20:729–737.
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