Cryoglobulinaemic vasculitis (CryoVas): pathology and causes

Evidence-based neurology checklist on cryoglobulinaemic vasculitis (cryovas): pathology and causes: Pathology This is a small vessel vasculitis It is caused by cryoglobulin deposits on the vessel walls There is B cell clonal proliferation These produce immunoglobulins that precipitate in the cold…

Pathology

  • This is a small vessel vasculitis
  • It is caused by cryoglobulin deposits on the vessel walls
  • There is B cell clonal proliferation
  • These produce immunoglobulins that precipitate in the cold
  • They precipitate at <37C and dissolve on warming
  • There may be associated antineutrophil cytoplasmic antibodies (ANCA)

Classification: Type I

Classification: Types II and III (mixed cryoglobulinaemia)

Infective causes

Autoimmune causes

Neoplastic causes

Other causes

Acronym

References

  1. Miller A, Chan M, Wiik A, Misbah SA, Luqmani RA. An approach to the diagnosis and management of systemic vasculitis. Clin Exp Immunol 2010; 160:143-160.
  2. Retamozo S, Díaz-Lagares C, Bosch X, et al. Life-threatening cryoglobulinemic patients with hepatitis C: clinical description and outcome of 279 patients. Medicine (Baltimore) 2013; 92:273-284.
  3. Hanna RM, So N, Kaldas M, et al. Case report: patient with hepatitis C, p-ANCA, and cryoglobulin antibodies presenting with necrotizing crescentic p-ANCA glomerulonephritis. Case Rep Nephrol Dial 2018; 8:161-170.
  4. Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D. Cryoglobulinemia vasculitis. Am J Med 2015; 128:950-955.
  5. Desbois AC, Cacoub P, Saadoun D. Cryoglobulinemia: an update in 2019. Joint Bone Spine 2019; 86:707-713.
  6. And 11 more. Subscribe to see the full list

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