Cryoglobulinaemic vasculitis (CryoVas): clinical features

Evidence-based neurology checklist on cryoglobulinaemic vasculitis (cryovas): clinical features: Systemic features Meltzer’s triad Fatigue Raynaud's phenomenon Acrocyanosis Gangrene Cold-induced urticaria Livedo reticularis Renal features Gastrointestinal features Neurological features: central…

Systemic features

  • Meltzer’s triad
  • Fatigue
  • Raynaud's phenomenon
  • Acrocyanosis
  • Gangrene 
  • Cold-induced urticaria
  • Livedo reticularis

Renal features

Gastrointestinal features

Neurological features: central

Neurological features: peripheral

Respiratory features

Cardiac features

Dermatological features

Endocrine features

Other features

Differential diagnosis

Complications

References

  1. Retamozo S, Díaz-Lagares C, Bosch X, et al. Life-threatening cryoglobulinemic patients with hepatitis C: clinical description and outcome of 279 patients. Medicine (Baltimore) 2013; 92:273-284.
  2. German A, Grotemeyer A, Rothhammer V, Doerfler A, Winkler J, Regensburger M. Pearls & Oy-sters: Reversible leukoencephalopathy and Parkinsonism due to CNS involvement in cryoglobulinemia. Neurology 2026; 106:e214622.
  3. Feldman L, Dhamne M, Li Y. Neurologic manifestations associated with cryoglobulinemia: A single center experience. J Neurol Sci 2019; 398:121-127.
  4. Thaunat O, Aaron L, Desbene C, et al. Type III cryoglobulinemia complicated by renal cortical necrosis. Am J Kidney Dis 2005; 45:e79-e81.
  5. Feldman L, Dhamne M, Li Y. Neurologic manifestations associated with cryoglobulinemia: a single center experience. J Neurol Sci 2019; 398:121-127.
  6. And 19 more. Subscribe to see the full list

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