Convulsive status epilepticus: treatment
Evidence-based neurology checklist on convulsive status epilepticus: treatment: Initial treatment options Intravenous Lorazepam 0.1mg/kg or 4mg: repeatable after 10mins Intravenous Diazepam: 10mg and repeatable Intramuscular Midazolam Alternative initial treatment options Second line treatment:…
Initial treatment options
- Intravenous Lorazepam 0.1mg/kg or 4mg: repeatable after 10mins
- Intravenous Diazepam: 10mg and repeatable
- Intramuscular Midazolam
Alternative initial treatment options
Second line treatment: intravenous after 20 minutes
Third line treatment: after 40 minutes
Emerging treatments
References
- Glauser T, Shinnar S, Gloss D, et al. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr 2016; 16:48-61.
- Meierkord H, Boon P, Engelsen B, et al. EFNS guideline on the management of status epilepticus in adults. Eur J Neurol 2010; 17:348-355.
- The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. NICE clinical guidelines [CG137]. January 2012.
- Trinka E. Phenobarbital in status epilepticus - rediscovery of an effective drug. Epilepsy Behav 2023; 141:109104.
- Detyniecki K, Van Ess PJ, Sequeira DJ, Wheless JW, Meng TC, Pullman WE. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial. Epilepsia 2019; 60:179
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