Convulsive status epilepticus: prognostic features

Evidence-based neurology checklist on convulsive status epilepticus: prognostic features: Clinical predictors of poor prognosis Older age: ≥65 years Potentially fatal aetiologies De novo onset in hospitalised patients Impairment of consciousness Prolonged seizure duration Focal neurological signs…

Clinical predictors of poor prognosis

  • Older age: ≥65 years
  • Potentially fatal aetiologies
  • De novo onset in hospitalised patients
  • Impairment of consciousness
  • Prolonged seizure duration
  • Focal neurological signs at onset
  • Medical complications
  • Inadequate Benzodiazepine dosing

Investigative predictors of poor prognosis

Risk factors for recurrent status epilepticus

Outcome prediction scales

References

  1. Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care 2012; 17:3-23.
  2. Atmaca MM, Bebek N, Baykan B, Gökyiğit A, Gürses C. Predictors of outcomes and refractoriness in status epilepticus: A prospective study. Epilepsy Behav 2017; 75:158-164.
  3. Rao SK, Mahulikar A, Ibrahim M, Shah A, Seraji-Bozorgzad N, Mohamed W. Inadequate benzodiazepine dosing may result in progression to refractory and non-convulsive status epilepticus. Epileptic Disord 2018; 20:265-269. 
  4. Nass RD, Motloch LJ, Paar V, et al. Blood markers of cardiac stress after generalized convulsive seizures. Epilepsia 2019; 60:201-210.
  5. Bonduelle T, Ollivier M, Trin K, et al. Association of peri-ictal MRI abnormalities with mortality, antiseizure medication refractoriness, and morbidity in status epilepticus. Neurology 2023; 100:e943-e953.
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