Chronic traumatic encephalopathy (CTE): pathology and imaging

Evidence-based neurology checklist on chronic traumatic encephalopathy (cte): pathology and imaging: Pathological features Hyperphosphorylated tau Astrocytic and neurofibrillary tangles Neurites TDP-43 may be positive β amyloid may be positive Magnetic resonance imaging (MRI) features

Pathological features

  • Hyperphosphorylated tau
  • Astrocytic and neurofibrillary tangles
  • Neurites
  • TDP-43 may be positive
  • β amyloid may be positive

Magnetic resonance imaging (MRI) features

References

  1. Saulle M, Greenwald BD. Chronic traumatic encephalopathy: a review. Rehabil Res Pract 2012; 2012:816069. 
  2. McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68:709-735.
  3. Baugh CM, Stamm JM, Riley DO, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav 2012; 6:244-254.
  4. McKee AC, Stern RA, Nowinski CJ, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 2013; 136:43-64.

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