Chronic traumatic encephalopathy (CTE): clinical features

Evidence-based neurology checklist on chronic traumatic encephalopathy (cte): clinical features: Etiology This is a progressive neurodegenerative disease It is the result of single or repetitive closed head injuries The trauma may be sub-concussive It is often associated with contact sports It is…

Etiology

  • This is a progressive neurodegenerative disease
  • It is the result of single or repetitive closed head injuries
  • The trauma may be sub-concussive
  • It is often associated with contact sports
  • It is possibly a result of immune-excitotoxicity

Risk factors

Epidemiological features

Cognitive features

Psychiatric features

Motor features

Other features

Differential diagnosis

References

  1. Saulle M, Greenwald BD. Chronic traumatic encephalopathy: a review. Rehabil Res Pract 2012; 2012:816069. 
  2. McKee AC, Cantu RC, Nowinski CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68:709-735.
  3. Baugh CM, Stamm JM, Riley DO, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav 2012; 6:244-254.
  4. McKee AC, Mez J, Abdolmohammadi B. Neuropathologic and clinical findings in young contact sport athletes exposed to repetitive head impacts. JAMA Neurol 2023 (Online ahead of print).

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