CGRP receptor antagonists (CGRP-RAs): general aspects
Evidence-based neurology checklist on cgrp receptor antagonists (cgrp-ras): general aspects: CGRP gene family members α- CGRP: this is the conventional CGRP β-CGRP Adrenomedullin Adrenomedullin 2 Amylin Calcitonin CGRP receptor subunits CGRP role in migraine pathogenesis Approved CGRP-RAs…
CGRP gene family members
- α- CGRP: this is the conventional CGRP
- β-CGRP
- Adrenomedullin
- Adrenomedullin 2
- Amylin
- Calcitonin
CGRP receptor subunits
CGRP role in migraine pathogenesis
Approved CGRP-RAs
Investigational intranasal CGRP-RAs
Indications
Discontinued CGRP-RAs
Re-starting after discontinuation
Synonym
References
- Russo AF. Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol 2015; 55:533-552.
- Voss T, Lipton RB, Dodick DW, et al. A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine. Cephalalgia 2016; 36:887-898.
- Scott LJ. Rimegepant: first approval. Drugs 2020; 80:741-746.
- Kish T. Emerging therapies for patients with difficult-to-treat migraine. P T 2018; 43:616-621.
- Croop R, Madonia J, Stock DA, et al. Zavegepant nasal spray for the acute treatment of migraine: a Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial. Headache 2022; 62:1153-1163.
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