Cerebral proliferative angiopathy (CPA)

Evidence-based neurology checklist on cerebral proliferative angiopathy (cpa): Pathology This is a brain vascular malformation Abnormal vascular channels are interspersed in functional brain parenchyma It results from uncontrolled angiogenesis There is a proliferative nidus Most are supratentorial…

Pathology

  • This is a brain vascular malformation
  • Abnormal vascular channels are interspersed in functional brain parenchyma
  • It results from uncontrolled angiogenesis
  • There is a proliferative nidus
  • Most are supratentorial but some are infratentorial

Pathological features

Demographic features

Clinical features

Complications

Differential diagnosis

Magnetic resonance imaging (MRI) brain

Cerebral angiogram

Treatment

References

  1. Palavani LB, Mitre LP, Almeida MV, et al. Presentation and management of cerebral proliferative angiopathy: a systematic review and meta-analysis on treatment outcomes. Neurosurg Rev 2024; 47:664.
  2. Hess RM, Zhang JF, Cappuzzo JM, Bregy A, Levy EI. Cerebral proliferative angiopathy presenting as subdural hematoma: a case report and systematic literature review. World Neurosurg 2022; 164:281-289.
  3. Kumar S, Sharma M, Srivastava T, Sinha VD. Infratentorial hemorrhagic cerebral proliferative angiopathy: A rare presentation of a rare disease. Asian J Neurosurg 2015; 10:240-242.
  4. Yamaki VN, Solla DJF, Telles JPM, et al. The current clinical picture of cerebral proliferative angiopathy: systematic review. Acta Neurochir (Wien) 2020; 162:1727-1733.
  5. Srivastava T, Gandhi A, Kumar R. Clinico-radiological features of cerebral proliferative angiopathy: a large case series from India. Neuroradiol J 2022; 35:742-750.
  6. And 4 more. Subscribe to see the full list

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