Cerebral cavernous malformations (cavernomas): clinical features
Evidence-based neurology checklist on cerebral cavernous malformations (cavernomas): clinical features: Demographic features The mean age at diagnosis is 45 years They affect males and females equally They are rare in children but more aggressive Giant cavernomas are more frequent in children…
Demographic features
- The mean age at diagnosis is 45 years
- They affect males and females equally
- They are rare in children but more aggressive
- Giant cavernomas are more frequent in children
Genetic risk factors
Acquired risk factors
Clinical features of cranial cavernomas
Clinical features of spinal cavernomas
References
- Petersen TA, Morrison LA, Schrader RM, Hart BL. Familial versus sporadic cavernous malformations: differences in developmental venous anomaly association and lesion phenotype. Am J Neuroradiol 2010; 31:377–382.
- Kuroedov D, Cunha B, Pamplona J, Castillo M, Ramalho J. Cerebral cavernous malformations: typical and atypical imaging characteristics. J Neuroimaging 2022 (Online ahead of print).
- Horne MA, Flemming KD, Su IC, et al; Cerebral Cavernous Malformations Individual Patient Data Meta-analysis Collaborators. Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data. Lancet Neurol 2015; 15:166-173.
- Aras Y, Dolas I, Dolen D, et al. Pediatric cerebral cavernous malformation: a single-centered experience of 23 cases. Turk Neurosurg 2023; 33:63-69.
- McDonald DA, Shi C, Shenkar R, et al. Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. Hum Mol Genet 2014; 23:4357-4370.
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