Cerebral cavernous malformations (cavernomas): bleeding risk

Evidence-based neurology checklist on cerebral cavernous malformations (cavernomas): bleeding risk: 5-year haemorrhage risk The risk is 8% for asymptomatic brainstem cavernomas The risk is 4% for asymptomatic non-brainstem cavernomas Subject-related bleeding risk factors Cavernoma-related bleeding…

5-year haemorrhage risk

  • The risk is 8% for asymptomatic brainstem cavernomas
  • The risk is 4% for asymptomatic non-brainstem cavernomas

Subject-related bleeding risk factors

Cavernoma-related bleeding risk factors

Factors that reduce the risk of haemorrhage

Factors that do not increase the risk of haemorrhage

References

  1. Petersen TA, Morrison LA, Schrader RM, Hart BL. Familial versus sporadic cavernous malformations: differences in developmental venous anomaly association and lesion phenotype. Am J Neuroradiol 2010; 31:377–382.
  2. Horne MA, Flemming KD, Su IC, et al; Cerebral Cavernous Malformations Individual Patient Data Meta-analysis Collaborators. Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data. Lancet Neurol 2015; 15:166-173. 
  3. Kuroedov D, Cunha B, Pamplona J, Castillo M, Ramalho J. Cerebral cavernous malformations: typical and atypical imaging characteristics. J Neuroimaging 2022 (Online ahead of print).
  4. Fleming KD, Limk MJ, Christianson TJH, et al. Prospective hemorrhage risk of intracerebral cavernous malformations. Neurology 2012; 78:632-636.
  5. Kashefiolasl S, Bruder M, Brawanski N, et al. A benchmark approach to hemorrhage risk management of cavernous malformations. Neurology 2018; 90:e856-e863.
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