Cerebral amyloid angiopathy (CAA): classification

Evidence-based neurology checklist on cerebral amyloid angiopathy (caa): classification: Hereditary CAA Piedmont type: caused by Leu705Val amyloid precursor protein (APP) mutations Dutch type: this is hereditary cerebral haemorrhage with amyloidosis (HCHWA-D) Iatrogenic CAA: causes Iatrogenic CAA:…

Hereditary CAA

  • Piedmont type: caused by Leu705Val amyloid precursor protein (APP) mutations
  • Dutch type: this is hereditary cerebral haemorrhage with amyloidosis (HCHWA-D)

Iatrogenic CAA: causes

Iatrogenic CAA: features

Other types

References

  1. Kozberg MG, van Veluw SJ, Frosch MP, Greenberg SM. Hereditary cerebral amyloid angiopathy, Piedmont-type mutation. Neurol Genet 2020; 6:e411. 
  2. Grand Moursel L, van der Graaf LM, Bulk M, van Roon-Mom WMC, van der Weerd L. Osteopontin and phospho-SMAD2/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy. Brain Pathol 2019; 29:793-802.
  3. Banerjee G, Samra K, Adams ME, et al. Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon. JNNP 2022 (Online ahead of print).
  4. Pikija S, Pretnar-Oblak J, Frol S, et al. Iatrogenic cerebral amyloid angiopathy: A multinational case series and individual patient data analysis of the literature. Int J Stroke 2023 (Online ahead of print).
  5. Pikija S, Toma A, Radlberger R, et al. Iatrogenic cerebral amyloid angiopathy in patients treated with cadaveric dura mater during childhood neurosurgery: a retrospective cohort study. Eur J Neurol  2025; 32:e70091.
  6. And 3 more. Subscribe to see the full list

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