Cefepime encephalopathy
Evidence-based neurology checklist on cefepime encephalopathy: Predisposing factors Older age Renal impairment: but it may occur with normal renal function Cerebral palsy Plasma concentration of Cefepime >35mg/L Demographic features Neurological features: status epilepticus Neurological features:…
Predisposing factors
- Older age
- Renal impairment: but it may occur with normal renal function
- Cerebral palsy
- Plasma concentration of Cefepime >35mg/L
Demographic features
Neurological features: status epilepticus
Neurological features: others
Electroencephalogram (EEG): features
Prevention
Treatment
References
- Payne LE, Gagnon DJ, Riker RR, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care 2017; 21:276.
- Fugate JE, Kalimullah EA, Hocker SE, Clark SL, Wijdicks EF, Rabinstein AA. Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Crit Care 2013; 17:R264.
- Appa AA, Jain R, Rakita RM, Hakimian S, Pottinger PS. Characterizing cefepime neurotoxicity: a systematic review. Open Forum Infect Dis 2017; 4:ofx170.
- Gangireddy VG, Mitchell LC, Coleman T. Cefepime neurotoxicity despite renal adjusted dosing. Scand J Infect Dis 2011; 43:827-829.
- Park HM, Noh Y, Yang JW, Shin DH, Lee YB. Cefepime-induced non-convulsive status epilepticus in a patient with normal renal function. J Epilepsy Res 2016; 6:97-99.
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