Catastrophic antiphospholipid syndrome (CAPS)

Evidence-based neurology checklist on catastrophic antiphospholipid syndrome (caps): Pathology This occurs in 1% of the cases It results from microvascular occlusion It is a result of multiple thrombosis developing rapidly Risk factors Neurological features Systemic features Diagnostic criteria…

Pathology

  • This occurs in 1% of the cases
  • It results from microvascular occlusion
  • It is a result of multiple thrombosis developing rapidly

Risk factors

Neurological features

Systemic features

Diagnostic criteria

Other differentials

Investigations

Treatment

Treatment of refractory cases

Outcome

References

  1. Stanescu C, Andronesi AG, Jurcut C, et al. Successful treatment of catastrophic antiphospholipid syndrome using rituximab: case report and review of the literature. Medicina (Kaunas) 2021; 57:912.
  2. Cervera R, Rodríguez-Pintó I, Espinosa G. The diagnosis and clinical management of the catstrophic antiphospholipid syndrome: a comprehensive review. J Autoimmun 2018; 92:1-11. 
  3. Mustafa R. Neurologic manifestations of catastrophic antiphospholipid syndrome. Curr Neurol Neurosci Rep 2022; 22:589-600. 
  4. Christopher N, Periaswamy G, Arunachalam VK, Mangalakumar V, Mehta P, Cherian M. Catastrophic antiphospholipid syndrome: a case series. Indian J Radiol Imaging 2022; 33:235-239.
  5. Kazzaz NM, McCune WJ, Knight JS. Treatment of catastrophic antiphospholipid syndrome. Curr Opin Rheumatol 2016; 28:218-227.
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