Carbamazepine: side effects

Evidence-based neurology checklist on carbamazepine: side effects: Teratogenic side effects Dysmorphic appearance: doll-like appearance with full cheeks and a small chin Spina bifida Cardiac malformations Dental anomalies Steven-Johnson syndrome: risk markers DRESS syndrome Hyponatraemia…

Teratogenic side effects

  • Dysmorphic appearance: doll-like appearance with full cheeks and a small chin
  • Spina bifida
  • Cardiac malformations
  • Dental anomalies

Steven-Johnson syndrome: risk markers

DRESS syndrome

Hyponatraemia

Neurological side effects

Haematological side effects

Cardiac side effects

Systemic side effects

Carbamazepine resistance

References

  1. Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J; Liverpool and Manchester Neurodevelopmental Study Group. Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed 2006; 91:F90-F95.
  2. Jentink J, Dolk H, Loane MA, et al; EUROCAT Antiepileptic Study Working Group. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 2010; 341:c6581.
  3. Verrotti A, Mencaroni E, Castagnino M, Zaccara G. Foetal safety of old and new antiepileptic drugs. Expert Opin Drug Saf 2015; 14:1563-1571. 
  4. Tomson T, Xue H, Battino D. Major congenital malformations in children of women with epilepsy. Seizure 2015; 28:46-50. 
  5. Güveli BT, Rosti RÖ, Güzeltaş A, et al. Teratogenicity of antiepileptic drugs. Clin Psychopharmacol Neurosci 2017; 15:19-27.
  6. And 23 more. Subscribe to see the full list

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