Carbamazepine: clinical use
Evidence-based neurology checklist on carbamazepine: clinical use: Mode of action and indication Carbamazepine is a voltage gated sodium channel inhibitor It is indicated for partial and generalised seizures Dosing Full blood count monitoring of Carbamazepine Long-term monitoring of Carbamazepine…
Mode of action and indication
- Carbamazepine is a voltage gated sodium channel inhibitor
- It is indicated for partial and generalised seizures
Dosing
Full blood count monitoring of Carbamazepine
Long-term monitoring of Carbamazepine (2-5 yearly)
Drug which reduce Carbamazepine blood levels
Drug which increase Carbamazepine blood levels
Drugs whose levels are reduced by Carbamazepine
References
- Ambrósio AF, Soares-Da-Silva P, Carvalho CM, Carvalho AP. Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem Res 2002; 27:121-130.
- Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010; 9:413-424.
- Porter RJ. How to initiate and maintain carbamazepine therapy in children and adults. Epilepsia 1987; 28(Suppl 3):S59-S63.
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Powell G, Saunders M, Marson AG. Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy. Cochrane Database Syst Rev 2014; 2:CD007124.
- And 7 more. Subscribe to see the full list
