Anti-seizure medications (ASMs): classification by metabolism

Evidence-based neurology checklist on anti-seizure medications (asms): classification by metabolism: Enzyme inducing AEDs Carbamazepine Eslicarbazapine Oxcarbazepine Perampanel Phenobarbitone Phenytoin Primidone Rufinamide Topiramate Non-enzyme inducing AEDs

Enzyme inducing AEDs

  • Carbamazepine
  • Eslicarbazapine
  • Oxcarbazepine
  • Perampanel
  • Phenobarbitone
  • Phenytoin
  • Primidone
  • Rufinamide
  • Topiramate

Non-enzyme inducing AEDs

References

  1. Johannessen SI, Landmark CJ. Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol 2010; 8:254-267.
  2. French JA, Krauss GL, Wechsler RT, et al. Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy: a randomized trial. Neurology 2015; 85:950-957.
  3. Lattanzi S, Cagnetti C, Foschi N, Provinciali L, Silvestrini M. Brivaracetam add-on for refractory focal epilepsy: a systematic review and meta-analysis. Neurology 2016; 86:1344-1352.
  4. Splinter MY. Efficacy of retigabine in adjunctive treatment of partial onset seizures in adults. J Cent Nerv Syst Dis 2013; 5:31-41.

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