Anti-MOG antibody disease (MOGAD): non-brainstem features

Evidence-based neurology checklist on anti-mog antibody disease (mogad): non-brainstem features: Spinal cord features Acute flaccid myelitis Isolated recurrent myelitis Relapsing lumbosacral myeloradiculitis Myelitis with normal MRI Peripheral features Other neurological features Psychiatric…

Spinal cord features

  • Acute flaccid myelitis
  • Isolated recurrent myelitis
  • Relapsing lumbosacral myeloradiculitis
  • Myelitis with normal MRI

Peripheral features

Other neurological features

Psychiatric features

Systemic associations

Cancer associations: very low risk

Reported associations with autoimmune encephalitis antibodies

References

  1. Dubey D, Pittock SJ, Krecke KN, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol 2018; doi: 10.1001/jamaneurol.2018.4053 (Epub ahead of print).
  2. Anis S, Regev K, Pittock SJ, Flanagan EP, Alcalay Y, Gadoth A. Isolated recurrent myelitis in a persistent MOG positive patient. Mult Scler Relat Disord 2019; 30:163-164. 
  3. Sundaram S, Nair SS, Jaganmohan D, Unnikrishnan G, Nair M. Relapsing lumbosacral myeloradiculitis: an unusual presentation of MOG antibody disease. Mult Scler 2019; 1:1352458519840747.
  4. Sechi E, Krecke KN, Pittock SJ, et al. Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies. Mult Scler 2020 (Epub ahead of print).
  5. Pérez CA, Garcia-Tarodo S, Troxell R. MRI-negative myelitis associated with myelin oligodendrocyte glycoprotein antibody spectrum demyelinating disease. Child Neurol Open 2019; 6:2329048X19830475.
  6. And 19 more. Subscribe to see the full list

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