Anti-MOG antibody disease (MOGAD): differentiation from AQP4 disorders

Evidence-based neurology checklist on anti-mog antibody disease (mogad): differentiation from aqp4 disorders: Clinical features supporting anti MOG Lack of female preponderance The presence of prodromal symptoms Concurrent acute disseminated encephalomyelitis (ADEM) More frequent monophasic course…

Clinical features supporting anti MOG

  • Lack of female preponderance
  • The presence of prodromal symptoms
  • Concurrent acute disseminated encephalomyelitis (ADEM)
  • More frequent monophasic course
  • Lower risk of relapse
  • Better outcome

Radiological features supporting anti MOG

Radiological features supporting AQP4

Radiological features supporting anti MOG and AQP4 equally

TRUE-MOGAD Score: ≥2 identifies MOGAD in people with MOG antibodies

References

  1. Dubey D, Pittock SJ, Krecke KN, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol 2019; 76:301-309.
  2. Höftberger R, Sepulveda M, Armangue T, et al. Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease. Mult Scler 2015; 21:866-874. 
  3. Salama S, Khan M, Shanechi A, Levy M, Izbudak I. MRI differences between MOG antibody disease and AQP4 NMOSD. Mult Scler 2020 (Epub ahead of print).
  4. Cobo-Calvo A, Ruiz A, Maillart E, et al; OFSEP and NOMADMUS Study Group. Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study. Neurology 2018; 90:e1858-e1869.
  5. Vilaseca A, Filippatou AG, Said Y, et al. TRUE-MOGAD Score: a novel scoring system to identify MOGAD among positive MOG-IgG test results. Neurol Neuroimmunol Neuroinflamm 2026; 13:e200563.

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