Anti LG1 VGCK autoimmune encephalitis: management
Evidence-based neurology checklist on anti lg1 vgck autoimmune encephalitis: management: Magnetic resonance imaging (MRI) This shows hippocampal T2 hyperintensities in 75% of cases These often evolve into mesial temporal sclerosis Lesions also seen in the basal ganglia Positron emission tomography…
Magnetic resonance imaging (MRI)
- This shows hippocampal T2 hyperintensities in 75% of cases
- These often evolve into mesial temporal sclerosis
- Lesions also seen in the basal ganglia
Positron emission tomography (PET) scan
Anti VGKC antibody test
Serum neurofilament light (NfL)
Cerebrospinal fluid (CSF) analysis
Initial treatment
Secondary treatment for refractory cases
References
- Lee R, Buckley C, Irani SR, Vincent A. Autoantibody testing in encephalopathies. Pract Neurol 2012; 12:4-13.
- Vincent A, Bien CG, Irani SR, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011; 10:759-772.
- Thieben MJ, Lennon VA, Boeve BF, Aksamit AJ, Keegan M, Vernino S. Potentially reversible autoimmune limbic encephalitis with neuronal potassium channel antibody. Neurology 2004; 62:1177-1182.
- Flanagan EP, Kotsenas AL, Britton JW, et al. Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures. Neurol Neuroimmunol Neuroinflamm 2015; 2:e161.
- Kim YE, Lim JS, Lee Y, Lee JH. Teaching NeuroImage: Glucose hypermetabolism in the basal ganglia: the decisive clue to the diagnosis of an unusual anti-LGI1 Encephalitis. Neurology 2023; 101:90-91.
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