Anti-glycine receptor syndrome: clinical features
Evidence-based neurology checklist on anti-glycine receptor syndrome: clinical features: Pathology This is caused by GlyRα1 antibodies These target the retina, the brainstem, and spinal cord Antibody titers correlate with disease severity Serum GlyRα1 antibody levels may be higher in serum than…
Pathology
- This is caused by GlyRα1 antibodies
- These target the retina, the brainstem, and spinal cord
- Antibody titers correlate with disease severity
- Serum GlyRα1 antibody levels may be higher in serum than CSF
Clinical phenotypes: PERM
Clinical phenotypes: others
Main clinical features
Brainstem features
Ophthalmic features
Psychiatric features
Other neurological features
Differential diagnosis
Prognosis
Acronym
References
- Hinson SR, Lopez-Chiriboga AS, Bower JH, et al. Glycine receptor modulating antibody predicting treatable stiff-person spectrum disorders. Neurol Neuroimmunol Neuroinflamm 2018; 5:e438.
- McKeon A, Martinez-Hernandez E, Lancaster E, et al. Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol 2013; 70:44-50.
- Iizuka T, Tominaga N, Kaneko J. Clinical spectrum of anti-glycine receptor antibody-associated disease. Rinsho Shinkeigaku 2013; 53:1063-1066.
- Crisp SJ, Balint B, Vincent A. Redefining progressive encephalomyelitis with rigidity and myoclonus after the discovery of antibodies to glycine receptors. Curr Opin Neurol 2017; 30:310-316.
- Carvajal-González A, Leite MI, Waters P, et al. Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes. Brain 2014; 137:2178-2192.
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