Anti-GAD cerebellar ataxia
Evidence-based neurology checklist on anti-gad cerebellar ataxia: Pathology This is caused by anti-GAD65 antibodies The antibodies may be paraneoplastic Demographic features Prodromal features Clinical features Associated autoimmune diseases Cerebrospinal fluid (CSF) analysis Magnetic resonance…
Pathology
- This is caused by anti-GAD65 antibodies
- The antibodies may be paraneoplastic
Demographic features
Prodromal features
Clinical features
Associated autoimmune diseases
Cerebrospinal fluid (CSF) analysis
Magnetic resonance imaging (MRI) brain
Acute treatment
Maintenance treatment
References
- Ariño H, Gresa-Arribas N, Blanco Y, et al. Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy. JAMA Neurol 2014; 71:1009-1016.
- Kuchling J, Shababi-Klein J, Nümann A, Gerischer LM, Harms L, Prüss H. GAD antibody-associated late-onset cerebellar ataxia in two female siblings. Case Rep Neurol 2014; 6:264-270.
- Bayreuther C, Hieronimus S, Ferrari P, Thomas P, Lebrun C. Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus. Diabetes Metab 2008; 34:386-388.
- Saiz A, Arpa J, Sagasta A, et al. Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity. Neurology 1997; 49:1026-1030.
