Alzheimer's Disease (AD) v frontotemporal dementia (FTD)

Evidence-based neurology checklist on alzheimer's disease (ad) v frontotemporal dementia (ftd): Clinical features more suggestive of FTD Younger onset age Higher levels of educational attainment Better mini mental state examination (MMSE) scores Better memory in the early stages Worse executive…

Clinical features more suggestive of FTD

  • Younger onset age
  • Higher levels of educational attainment
  • Better mini mental state examination (MMSE) scores
  • Better memory in the early stages
  • Worse executive and language functions
  • Worse verbal scores
  • A higher frequency of criminal behaviour

Cerebrospinal fluid (CSF) analysis

Magnetic resonance imaging (MRI) brain

Positron emission tomography (PET) scan

References

  1. Hutchinson AD, Mathias JL. Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review. JNNP 2007; 78:917-928.
  2. Haußmann R, Krug C, Noppes F, Brandt M, Lange J, Donix M. Criminal behavior in frontotemporal dementia and Alzheimer's disease. Nervenarzt 2022; 93:59-67.
  3. Liljegren M, Naasan G, Temlett J, et al. Criminal behavior in frontotemporal dementia and Alzheimer disease. JAMA Neurol 2015; 72:295-300. 
  4. de Souza LC, Lamari F, Belliard S, et al. Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias. JNNP 2011; 82:240-246.
  5. de Jong D, Jansen RWMM, Pijnenburg YAL, et al. CSF neurofilament proteins in the differential diagnosis of dementia. JNNP 2007; 78:936-938.
  6. And 2 more. Subscribe to see the full list

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