Alzheimer’s disease (AD): preventative measures

Evidence-based neurology checklist on alzheimer’s disease (ad): preventative measures: Measures with very strong evidence Education Cognitive activity Reduction of high body mass index in late life Treatment of hyperhomocysteinaemia: with folic acid, vitamin B12 and vitamin B6 Treatment of…

Measures with very strong evidence

  • Education
  • Cognitive activity
  • Reduction of high body mass index in late life
  • Treatment of hyperhomocysteinaemia: with folic acid, vitamin B12 and vitamin B6
  • Treatment of depression
  • Stress reduction
  • Treatment of diabetes
  • Prevention of head trauma
  • Controlling mid-life hypertension
  • Treat of orthostatic hypotension

Measures with weaker evidence

Measures of uncertain benefit

Measures not recommended

References

  1. Yu JT, Xu W, Tan CC, et al. Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. JNNP 2020 (Online ahead of print).
  2. Rakesh G, Szabo ST, Alexopoulos GS, Zannas AS. Strategies for dementia prevention: latest evidence and implications. Ther Adv Chronic Dis 2017; 8:121-136.
  3. Sun M, Chen W-M, Wu S-Y, et al. Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction. Brain 2023 (Online ahead of print).
  4. López-Ortiz S, Lista S, Valenzuela PL, et al. Effects of physical activity and exercise interventions on Alzheimer's disease: an umbrella review of existing meta-analyses. J Neurol 2023; 270:711-725.

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