Agyrophilic grain disease (AGD): clinical features

Evidence-based neurology checklist on agyrophilic grain disease (agd): clinical features: Demographic features This is a four-repeat tauopathy of older people The prevalence is 9.3% in people >65 years It may present in people as young as 49 years Risk factors Neurological features: dementia…

Demographic features

  • This is a four-repeat tauopathy of older people
  • The prevalence is 9.3% in people >65 years
  • It may present in people as young as 49 years

Risk factors

Neurological features: dementia

Neurological features: others

Psychiatric features

Systemic features

Associated disorders

Possible associated disorders

References

  1. Yokota O, Miki T, Ikeda C, et al. Neuropathological comorbidity associated with argyrophilic grain disease. Neuropathology 2018; 38:82-97. 
  2. Grinberg LT, Heinsen H. Argyrophilic grain disease: an update about a frequent cause of dementia. Dement Neuropsychol 2009; 3:2-7. 
  3. Rodriguez RD, Grinberg LT. Argyrophilic grain disease: an underestimated tauopathy. Dement Neuropsychol 2015; 9:2-8. 
  4. Rodriguez RD, Suemoto CK, Molina M, et al. Argyrophilic grain disease: demographics, clinical, and neuropathological features from a large autopsy study. J Neuropathol Exp Neurol 2016; 75:628-635. 
  5. Jicha GA, Petersen RC, Knopman DS, et al. Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. J Neuropathol Exp Neurol 2006; 65:602-609.
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