Wernicke’s encephalopathy: treatment

Evidence-based neurology checklist on wernicke’s encephalopathy: treatment: Pre-thiamine replacement tests Red cell trans-ketolase Direct measurement of thiamine in blood Thiamine replacement therapy Thiamine prophylactic therapy: indications Potential cognitive treatments

Pre-thiamine replacement tests

  • Red cell trans-ketolase
  • Direct measurement of thiamine in blood

Thiamine replacement therapy

Thiamine prophylactic therapy: indications

Potential cognitive treatments

References

  1. Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone MA. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol 2010; 17:1408-1418.
  2. Zuccoli G, Santa Cruz D, Bertolini M, Rovira A, Gallucci M, Carollo C, Pipitone N. MR imaging findings in 56 patients with Wernicke encephalopathy: nonalcoholics may differ from alcoholics. Am J Neuroradiol 2009; 30:171-176. 
  3. Pereira DB, Pereira ML, Gasparetto EL. Nonalcoholic Wernicke encephalopathy with extensive cortical involvement: cortical laminar necrosis and hemorrhage demonstrated with susceptibility-weighted MR phase images. Am J Neuroradiol 2011; 32:E37-E38. 
  4. Doherty MJ, Watson NF, Uchino K, Hallam DK, Cramer SC. Diffusion abnormalities in patients with Wernicke encephalopathy. Neurology 2002; 58:655-657.
  5. Day E, Bentham PW, Callaghan R, Kuruvilla T, George S. Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol. Cochrane Database Syst Rev 2013; 7:CD004033. 
  6. And 2 more. Subscribe to see the full list

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