Triptans: drug interactions

Evidence-based neurology checklist on triptans: drug interactions: Interactions with anti-depressants SSRIs: but risk of serious serotonin syndrome is low Tricyclics Nefazodone Trazodone Venlafaxine Bupropion Monoamine oxidase inhibitors (MAOI): these increase the bioavailability of some triptans…

Interactions with anti-depressants

  • SSRIs: but risk of serious serotonin syndrome is low
  • Tricyclics
  • Nefazodone
  • Trazodone
  • Venlafaxine
  • Bupropion
  • Monoamine oxidase inhibitors (MAOI): these increase the bioavailability of some triptans

Other interactions

References

  1. Demaagd G. The pharmacological management of migraine, part 1: overview and abortive therapy. P T 2008; 33:404-416.
  2. Tepper SJ. Safety and rational use of the triptans. Med Clin North Am 2001; 85:959-970.
  3. Millson DS, Tepper SJ, Rapoport AM. Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother 2000; 1:391-404. 
  4. Gillman PK. Triptans, serotonin agonists, and serotonin syndrome (serotonin toxicity): a review. Headache 2010; 50:264-272.

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