Systemic vasculitic peripheral neuropathy (PN): investigations

Evidence-based neurology checklist on systemic vasculitic peripheral neuropathy (pn): investigations: Basic investigations Full blood count (FBC) Eosinophils Erythrocyte sedimentation rate (ESR) C-reactive protein (CRP) Fasting glucose HbA1C Renal and liver function tests Urinalysis Rheumatoid…

Basic investigations

  • Full blood count (FBC)
  • Eosinophils
  • Erythrocyte sedimentation rate (ESR)
  • C-reactive protein (CRP)
  • Fasting glucose
  • HbA1C
  • Renal and liver function tests
  • Urinalysis
  • Rheumatoid factor (RF)
  • Protein electrophoresis

Autoantibodies

Infection screen

Other blood tests

Genetic tests

Imaging

Nerve biopsy: predictors of positive findings

Other tests

References

  1. Collins MP, Dyck JB, Gronseth GS, et al. Peripheral Nerve Society guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of non-systemic vasculitic neuropathy: executive summary. J Peripher Nerv Syst 2010; 15:176-184.
  2. Gorson KC. Therapy for vasculitic neuropathies. Curr Treat Options Neurol 2006; 8:105-117.
  3. Gorson KC. Vasculitic neuropathies: an update. Neurologist 2007; 13:12-19.
  4. Goedee HS, van der Pol, WL, van Asseldonk J-T H, et al. Nerve sonography to detect peripheral nerve involvement in vasculitis syndromes. Neurol Clin Pract 2016; 6:293-303.
  5. Nathani D, Barnett MH, Spies J, Pollard J, Wang MX, Kiernan MC. Vasculitic neuropathy: comparison of clinical predictors with histopathological outcome. Muscle Nerve 2019; 59:643-649. 

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