Sudden unexpected death in epilepsy (SUDEP): epilepsy-related risk factors
Evidence-based neurology checklist on sudden unexpected death in epilepsy (sudep): epilepsy-related risk factors: Pathological risk factors Dentate gyrus abnormalities Neuropeptide depletion in the amygdala Reduced cortical adenosine receptors Increased neuronal adenosine receptors Seizure-related…
Pathological risk factors
- Dentate gyrus abnormalities
- Neuropeptide depletion in the amygdala
- Reduced cortical adenosine receptors
- Increased neuronal adenosine receptors
Seizure-related risk factors
Epilepsy-related risk factors
Prolonged post-ictal generalised EEG suppression (PGES)
Sudden spontaneous atraumatic arterial dissections (SAAADs)
Antiepileptic drug (AED) related risk factors
Doubtful risk factors: polytherapy
Doubtful risk factors: others
References
- Kinney HC, Cryan JB, Haynes RL, et al. Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability. Acta Neuropathol 2015; 129:65-80.
- Somani A, Perry C, Patodia S, et al. Neuropeptide depletion in the amygdala in sudden unexpected death in epilepsy: a postmortem study. Epilepsia 2020; 61:310-318.
- Patodia S, Paradiso B, Garcia M, Ellis M, Diehl B, Thom M, Devinsky O. Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. Epilepsia 2020 (Epub ahead of print).
- Hesdorffer DC, Tomson T, Benn E, et al. Combined analysis of risk factors for SUDEP. Epilepsia 2011; 52:1150-1159.
- So EL, Bainbridge J, Buchhalter JR, et al. Report of the American Epilepsy Society and the Epilepsy Foundation Joint Task Force on sudden unexplained death in epilepsy. Epilepsia 2009; 50:917-922.
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