Spina bifida: risk factors
Evidence-based neurology checklist on spina bifida: risk factors: Genetic mutations MTHFR VANGL1 VANGL2 FUZ CCL2 CELSR1 TBXT Other genetic risk factors Maternal vitamin and mineral deficiencies Maternal co-morbidities Maternal drugs and toxins exposure Possible risk factors Curranino syndrome
Genetic mutations
- MTHFR
- VANGL1
- VANGL2
- FUZ
- CCL2
- CELSR1
- TBXT
Other genetic risk factors
Maternal vitamin and mineral deficiencies
Maternal co-morbidities
Maternal drugs and toxins exposure
Possible risk factors
Curranino syndrome
References
- Mitchell LE, Adzick NS, Melchionne J, Pasquariello PS, Sutton LN, Whitehead AS. Spina bifida. Lancet 2004; 364:1885–1895.
- Northrup H, Volcik KA. Spina bifida and other neural tube defects. Curr Probl Pediatr 2000; 30:313-332.
- Hassan AS, Du YL, Lee SY, Wang A, Farmer DL. Spina bifida: a review of the genetics, pathophysiology and emerging cellular therapies. J Dev Biol 2022; 10:22.
- Kole MJ, Fridley JS, Jea A, Bollo RJ. Currarino syndrome and spinal dysraphism. J Neurosurg Pediatr 2014; 13:685-689.
