Small vessel disease (SVD): clinical features

Evidence-based neurology checklist on small vessel disease (svd): clinical features: Clinical manifestations Stroke Bleeding after thrombolysis Dementia Seizures Depression Gait impairment Falls Incontinence Impaired driving Poor prognostic features

Clinical manifestations

  • Stroke
  • Bleeding after thrombolysis
  • Dementia
  • Seizures
  • Depression
  • Gait impairment
  • Falls
  • Incontinence
  • Impaired driving

Poor prognostic features

References

  1. Grueter BE, Schulz UG. Age-related cerebral white matter disease (leukoaraiosis): a review. Postgrad Med J 2012; 88:79-87.
  2. Kwon HM, Lynn MJ, Turan TN, et al; SAMMPRIS Investigators. Frequency, risk factors, and outcome of coexistent small vessel disease and intracranial arterial stenosis: results from the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial. JAMA Neurol 2016; 73:36-42. 
  3. Melkas S, Putaala J, Oksala NKJ, et al. Small-vessel disease relates to poor poststroke survival in a 12-year follow-up. Neurology 2011; 76:734-739.
  4. Jokinen H, Lipsanen J, Schmidt R, et al. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology 2012; 78:1785-1792.
  5. Inzitari D, Piracucci G, Poggesi A, et al. Changes in white matter as determinant of global functional decline in older independent outpatients: the year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 2009; 339: b2477.
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