Small fiber neuropathy: treatment of neuropathic pain

Evidence-based neurology checklist on small fiber neuropathy: treatment of neuropathic pain: First line treatments Tricyclic antidepressants Serotonin norepinephrine reuptake inhibitors (SNRIs) Calcium channel α-2-delta (CACNA2D) ligands 5% topical lidocaine patch Second line treatments: opioids…

First line treatments

  • Tricyclic antidepressants
  • Serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Calcium channel α-2-delta (CACNA2D) ligands
  • 5% topical lidocaine patch

Second line treatments: opioids

Third line treatments: antiepileptic drugs (AEDs)

Third line treatments: others

Fourth line treatments

Investigational treatments

References

  1. Dworkin RH, O'Connor AB, Backonja M, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007; 132:237-251.
  2. Moulin DE, Clark AJ, Gilron I, et al. Pharmacological management of chronic neuropathic pain-consensus statement and guidelines from the Canadian Pain Society. Pain Res Manage 2007; 12:13-21.
  3. Attal N, Cruccu G, Baron R, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 2010; 17:1113-1123.
  4. Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol 2010; 9:807-819.
  5. Neuropathic pain: the pharmacological management of neuropathic pain in adults in non-specialist settings. NICE Clinical Guidance [CG96]. March 2010.
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