SLIPPERS

Evidence-based neurology checklist on slippers: Pathology This is supratentorial lymphocytic inflammation with parenchymal enhancement responsive to steroids It is a T-cell medicated perivascular inflammatory disorder Clinical features Course Differential diagnosis Magnetic resonance imaging (MRI)…

Pathology

  • This is supratentorial lymphocytic inflammation with parenchymal enhancement responsive to steroids
  • It is a T-cell medicated perivascular inflammatory disorder

Clinical features

Course

Differential diagnosis

Magnetic resonance imaging (MRI) brain

Cerebrospinal fluid (CSF) analysis

Brain biopsy features

Treatment

References

  1. Tsibonakis A, Theodorou A, Korkolopoulou P, Tsivgoulis G. Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: a potentially overlooked diagnosis. Ann Neurol 2024; 95:407-409.
  2. Sudhakar V, Gersey Z, Polster SP, Mantica M, Zenonos G. Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: a case report and literature review. Surg Neurol Int 2021; 12:327.
  3. Khan A, Khan MM, Al-Bozom IA, Baregzai Y, Ibrahim W, Hammadi F. The elusive SLIPPERS Syndrome (supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids): a case report and literature review. Int Med Case Rep J 2023; 16:357-361.
  4. Freua F, Mahler JV, Lima PLGSB, et al. Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids (SLIPPERS)-does it really exist? Brain Sci 2023; 13:1191.
  5. Fahimdanesh K, White J, Tsai M, Cevallos C, Feng J. SLIPPERS syndrome: clinical heterogeneity and management challenges in two case studies. Neurology 2024; 103(Suppl 1): S12-S13.

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