Sjogren’s syndrome: neurological features

Evidence-based neurology checklist on sjogren’s syndrome: neurological features: Demographic features Neurological involvement occurs in 20% of cases These precede the diagnosis of Sjogren’s syndrome in about 80-90% of cases Central nervous system (CNS) involvement occurs in more than 50% of cases…

Demographic features

  • Neurological involvement occurs in 20% of cases
  • These precede the diagnosis of Sjogren’s syndrome in about 80-90% of cases
  • Central nervous system (CNS) involvement occurs in more than 50% of cases
  • Peripheral nerves are involved in > 60% of cases

Variant presentations

Central features

Dorsal root ganglionopathy (DRG)

Cranial mononeuropathies

Peripheral neuropathy (PN): types

Other features

References

  1. Delalande S, de Seze J, Fauchais AL, et al. Neurologic manifestations in primary Sjögren syndrome: a study of 82 patients. Medicine (Baltimore) 2004; 83:280-291.
  2. Massara A, Bonazza S, Castellino, et al. Central nervous system involvement in Sjogren's syndrome: unusual, but not unremarkable-clinical, serological characteristics and outcomes in a large cohort of Italian patients. Rheumatology 2010; 49:1540-1549.
  3. Mori K, Iijima M, Koike H, et al. The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain 2005; 128:2518-2534.
  4. Birnbaum J. Peripheral nervous system manifestations of Sjögren syndrome: clinical patterns, diagnostic paradigms, etiopathogenesis, and therapeutic strategies. Neurologist 2010; 16:287-297.
  5. Chai J, Herrmann DN, Stanton M, Barbano RL, Logigian EL. Painful small-fiber neuropathy in Sjogren syndrome. Neurology 2005; 65:925-927.
  6. And 3 more. Subscribe to see the full list

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