Scrub typhus: management

Evidence-based neurology checklist on scrub typhus: management: Immunological investigations IgM enzyme-linked immunosorbent assay (ELISA) Immunofluorescence assay (IFA) Immunochromatographic test (ICT) The Weil–Felix test Loop-mediated isothermal amplification assay (LAMP) Polymerase chain…

Immunological investigations

  • IgM enzyme-linked immunosorbent assay (ELISA)
  • Immunofluorescence assay (IFA)
  • Immunochromatographic test (ICT)
  • The Weil–Felix test
  • Loop-mediated isothermal amplification assay (LAMP)
  • Polymerase chain reaction (PCR)
  • Metagenomic next-generation sequencing (mNGS)

Laboratory features

Cerebrospinal fluid (CSF) analysis

Treatment

References

  1. Basu S, Chakravarty A. Neurological manifestations of scrub typhus. Curr Neurol Neurosci Rep 2022; 22:491-498.
  2. Alam AM, Gillespie CS, Goodall J, et al. Neurological manifestations of scrub typhus infection: A systematic review and meta-analysis of clinical features and case fatality. PLoS Negl Trop Dis 2022; 16:e0010952.
  3. Garg D, Manesh A. Neurological facets of scrub typhus: a comprehensive narrative review. Ann Indian Acad Neurol 2021; 24:849-864.

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