Rosai-Dorfman disease (RDD): pathology

Evidence-based neurology checklist on rosai-dorfman disease (rdd): pathology: Description RDD is a non-Langerhans cell reactive histiocytic disorder It is a non-neoplastic lymphoproliferative disease It primarily affects the lymph nodes Extranodal involvement occurs in 50% of cases Pathological…

Description

  • RDD is a non-Langerhans cell reactive histiocytic disorder
  • It is a non-neoplastic lymphoproliferative disease
  • It primarily affects the lymph nodes
  • Extranodal involvement occurs in 50% of cases

Pathological features

Reported associated gene mutations

Associated autoimmune disorders

Associated neoplastic disorders

Possible associated viral disorders

Synonyms

References

  1. Qin G, Ye J, Lan S, et al. Rosai-Dorfman disease with spinal and multiple intracranial involvement: a case report and literature review. Br J Neurosurg 2019; 18:1-5.
  2. Gilani K, Kuntz S, Munoz DG, Schneider R. Pearls & Oy-sters: Rosai-Dorfman disease of the central nervous system. Neurology 2021 (Online ahead of print).
  3. Varrassi M, Corridore A, Tommasino E, et al. MR imaging of cerebral involvement of Rosai-Dorfman disease: a single-centre experience with review of the literature. Radiol Med 2021; 126:89-98.
  4. Abla O, Jacobsen E, Picarsic J, et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. Blood 2018; 131:2877-2890.
  5. Baassiri W, Moussalem CK, Massaad E, Zeidan YH, Darwish H. Craniocervical Rosai-Dorfman Disease involving the vertebral artery: case report and literature review. World Neurosurg 2020; 133:69-73.

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