ROHHAD: management

Endocrine investigations

• Adrenocortical insufficiency
• Growth hormone (GH) deficiency
• Hypothyroidism
• Hyperprolactinemia
• Hypernatraemia
• Inappropriate antidiuretic hormone secretion (SIADH)

Cerebrospinal fluid (CSF) analysis

Magnetic resonance imaging (MRI) brain

Polysomnography

Immunosuppression treatment

Other treatments

Acronym

Synonym

References

1. Ize-Ludlow D, Gray JA, Sperling MA, et al . Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. Pediatrics 2007; 120:e179-e188.
2. Maksoud I, Kassab L. Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation syndrome. Avicenna J Med 2015; 5:89-94.
3. Mandel-Brehm C, Benson LA, Tran B, Kung AF, et al. ZSCAN1 autoantibodies are associated with pediatric paraneoplastic ROHHAD. Ann Neurol 2022; 92:279-291.
4. Serafim AB, Olivé-Cirera G, Ortega-González Á, et al. Antibodies against ZSCAN1 in pediatric and adult patients with non-paraneoplastic ROHHAD syndrome. Neurol Neuroimmunol Neuroinflamm 2024; 11:e200276.
5. Aljabban L, Kassab L, Bakoura NA, Alsalka MF, Maksoud I.J Rapid-onset obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation and neuroendocrine tumor syndrome with a homogenous enlargement of the pituitary gland: a case report. Med Case Rep 2016; 10:328.
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Related checklists

• ROHHAD: systemic features
• ROHHAD: neurological features