Recurrent embolic stroke on treatment

Evidence-based neurology checklist on recurrent embolic stroke on treatment: Frequency This occurs in about 15% of anticoagulated people with atrial fibrillation (AF) The annual risk is 3.2 - 6.5% per year Neurological risk factors Cardiac risk factors Systemic risk factors Management

Frequency

  • This occurs in about 15% of anticoagulated people with atrial fibrillation (AF)
  • The annual risk is 3.2 - 6.5% per year

Neurological risk factors

Cardiac risk factors

Systemic risk factors

Management

References

  1. McCabe JJ, Cheung Y, Foley M, et al. Residual risk of recurrent stroke despite anticoagulation in patients with atrial fibrillation: a systematic review and meta-analysis. JAMA Neurol 2025 (Online ahead of print).
  2. Cheung Y, Foley M, Bradley D, et al. Clinical and biomarker determinants for recurrent stroke in patients with atrial fibrillation: a systematic review and meta-analysis. Neurology 2025; 104:e210061.
  3. Broukhim M, Halperin JL. Stroke prevention in the high-risk atrial fibrillation patient: medical management. Curr Cardiol Rep 2011; 13:9-17.
  4. Chan PH, Huang D, Hai JJ, et al. Stroke prevention using dabigatran in elderly Chinese patients with atrial fibrillation. Heart Rhythm 2016; 13:366-373.
  5. Masjuan J, Salido L, DeFelipe A, et al. Oral anticoagulation and left atrial appendage closure: a new strategy for recurrent cardioembolic stroke. Eur J Neurol 2019; 26:816-820.
  6. And 2 more. Subscribe to see the full list

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