Radiation induced toxicity: treatment

Evidence-based neurology checklist on radiation induced toxicity: treatment: Symptomatic treatment Analgesics Benzodiazepines: for paraesthesias Tricyclic antidepressants Quinine for cramps Carbamazepine: for myokymia Physical therapy Treatments of doubtful benefit Emerging treatments

Symptomatic treatment

  • Analgesics
  • Benzodiazepines: for paraesthesias
  • Tricyclic antidepressants
  • Quinine for cramps
  • Carbamazepine: for myokymia
  • Physical therapy

Treatments of doubtful benefit

Emerging treatments

References

  1. Gosk J, Rutowski R, Reichert P, Rabczyński J. Radiation-induced brachial plexus neuropathy-aetiopathogenesis, risk factors, differential diagnostics, symptoms and treatment. Folia Neuropathol 2007; 45:26-30.
  2. Delanian S, Lefaix JL, Pradat PF. Radiation-induced neuropathy in cancer survivors. Radiother Oncol 2012; 105:273-282.
  3. Peng G, Masood K, Gantz O, Sinha U. Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer. J Surg Oncol 2016; 114:27-31.
  4. Patel V, McGurk M. Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy. Br J Oral Maxillofac Surg 2017; 55:235-241.
  5. Delanian S, Lefaix JL, Maisonobe T, Salachas F, Pradat PF. Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo). J Neurol Sci 2008; 275:164-166.

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