Primary central nervous system lymphoma (PCNSL): treatment

Evidence-based neurology checklist on primary central nervous system lymphoma (pcnsl): treatment: Whole brain radiotherapy (WBRT) with chemotherapy Methotrexate Cytarabine Vincristine Procarbazine Rituximab Teniposide Carmustine Methylprednisolone Chemotherapy alone Salvage treatment for relapses…

Whole brain radiotherapy (WBRT) with chemotherapy

  • Methotrexate
  • Cytarabine
  • Vincristine
  • Procarbazine
  • Rituximab
  • Teniposide
  • Carmustine
  • Methylprednisolone

Chemotherapy alone

Salvage treatment for relapses

Steroids

Surgery

Novel treatments

References

  1. Algazi AP, Kadoch C, Rubenstein JL. Biology and treatment of primary central nervous system lymphoma. Neurotherapeutics 2009; 6:587-597.
  2. Ekenel M, DeAngelis LM. Treatment of primary central nervous system lymphoma. Curr Treat Options Neurol 2007; 9:271-282.
  3. Ahluwalia MS, Peereboom DM. Primary central nervous system lymphoma. Curr Treat Options Neurol 2010; 12:347-359.
  4. Porter AB, Giannini C, Kaufmann T, et al. Primary central nervous lymphoma can be histologically diagnosed after previous corticosteroid use: a pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma. Ann Neurol 2008; 63:662-667.
  5. Grommes C, Nayak L, Tun HW, Batchelor TT. Introduction of novel agents in the treatment of primary CNS lymphoma. Neuro Oncol 2019; 21:306-313.

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