Pregnancy and multiple sclerosis (MS): relapse management
Evidence-based neurology checklist on pregnancy and multiple sclerosis (ms): relapse management: Demographics of relapses in pregnancy Pregnancy is associated with a reduced incidence of MS relapses The relapse rate in pregnancy is about 17% Relapses usually occur in the first and third trimesters…
Demographics of relapses in pregnancy
- Pregnancy is associated with a reduced incidence of MS relapses
- The relapse rate in pregnancy is about 17%
- Relapses usually occur in the first and third trimesters
- A high number of pregnancies protects against relapses in pregnancy
- The risk of post-partum and post abortion relapse is high
- The high post-partum relapse risk is reduced by
- The relapse rate returns to baseline 12 months post-partum
- Serum neurofilament (NfL) levels predict the risk of relapse in pregnancy
Risk factors for relapses in pregnancy
Risk factors for post-partum relapses
Management of relapses in pregnancy
References
- Ponsonby AL, Lucas RM, van der Mei IA, et al. Offspring number, pregnancy, and risk of a first clinical demyelinating event: The AusImmune Study. Neurology 2012; 78:867-874.
- Lai W, Kinoshita M, Peng A, et al. Does pregnancy affect women with multiple sclerosis? A prospective study in Western China. J Neuroimmunol 2018; 321:24-28.
- Houtchens MK, Edwards NC, Phillips AL. Relapses and disease-modifying drug treatment in pregnancy and live birth in US women with MS. Neurology 2018; 91:e1570-e1578.
- Alroughani R, Alowayesh MS, Ahmed SF, Behbehani R, Al-Hashel J. Relapse occurrence in women with multiple sclerosis during pregnancy in the new treatment era. Neurology 2018; 90:e840-e846.
- Karnad DR, Guntupalli KK. Neurologic disorders in pregnancy. Crit Care Med 2005; 33(10 Suppl):S362-371.
- And 12 more. Subscribe to see the full list
