Phenytoin: clinical use

Evidence-based neurology checklist on phenytoin: clinical use: Mode of action Phenytoin inhibits voltage gated sodium channels (VGSC) It promotes sodium efflux from neurones Phosphenytoin is a phenytoin pro-drug Indications Dosing Long-term monitoring (2-5 yearly)

Mode of action

  • Phenytoin inhibits voltage gated sodium channels (VGSC)
  • It promotes sodium efflux from neurones
  • Phosphenytoin is a phenytoin pro-drug

Indications

Dosing

Long-term monitoring (2-5 yearly)

References

  1. Zaccara G, Cincotta A, Borgheresi F, Balestrieri F. Adverse motor effects induced by antiepileptic drugs. Epileptic Disord 2004; 6:153-168.
  2. Asconapé JJ. Some common issues in the use of antiepileptic drugs. Semin Neurol 2002; 22:27-39. 
  3. Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010; 9:413-424. 
  4. Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
  5. Popławska M, Borowicz KK, Czuczwar SJ. The safety and efficacy of fosphenytoin for the treatment of status epilepticus. Expert Rev Neurother 2015; 15:983-992.
  6. And 1 more. Subscribe to see the full list

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