Parkinson's disease (PD): hyposmia

Evidence-based neurology checklist on parkinson's disease (pd): hyposmia: Demographic features Hyposmia occurs early in 70-90% of PD cases It precedes motor features by years It is worse in males Clinical presentation Clinical correlates Assessment

Demographic features

  • Hyposmia occurs early in 70-90% of PD cases
  • It precedes motor features by years
  • It is worse in males

Clinical presentation

Clinical correlates

Assessment

References

  1. Doty RL. Olfaction in Parkinson's disease and related disorders. Neurobiol Dis 2012; 46:527-552.
  2. Rossi M, Escobar AM, Bril A, et al. Motor features in Parkinson's disease with normal olfactory function. Mov Disord 2016; 31:1414-1417. 
  3. Hawkes C. Olfaction in neurodegenerative disorder. Mov Disord 2003; 18:364-372.
  4. Gjerde KV, Müller B, Skeie GO, Assmus J, Alves G, Tysnes OB. Hyposmia in a simple smell test is associated with accelerated cognitive decline in early Parkinson's disease. Acta Neurol Scand 2018; 138:508-514.
  5. Wattendorf E, Welge-Lussen A, Fiedler K, et al. Olfactory impairment predicts brain atrophy in Parkinson's disease. J Neurosci 2009; 29:15410-15411.
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