Panayiotopoulos syndrome (PS)

Evidence-based neurology checklist on panayiotopoulos syndrome (ps): Seizures These start in early or mid-childhood Most seizures occur in sleep They are usually prolonged episodes Autonomic features Non-autonomic features Unusual features Progression Electroencephalogram (EEG) Differential…

Seizures

  • These start in early or mid-childhood
  • Most seizures occur in sleep
  • They are usually prolonged episodes

Autonomic features

Non-autonomic features

Unusual features

Progression

Electroencephalogram (EEG)

Differential diagnosis

Synonym

References

  1. Panayiotopoulos CP, Michael M, Sanders S, Valeta T, Koutroumanidis M. Benign childhood focal epilepsies: assessment of established and newly recognized syndromes. Brain 2008; 131:2264-2286.
  2. Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics 2006; 118:e1237-e1243.
  3. Semprino M, Galicchio S, Espeche A, et al. Panayiotopoulos syndrome: unusual clinical manifestations. Epilepsy Behav 2022; 128:108552.
  4. Berg E, Focke NKN, Brockmann K. Clinical differentiation of self-limited epilepsy with autonomic seizures (Panayiotopoulos syndrome) and childhood migraine. Neurol Clin Pract 2026; 16:e200630.

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