Oxcarbazepine: adverse effects
Evidence-based neurology checklist on oxcarbazepine: adverse effects: Dermatological side effect: skin eruption A maculopapular skin eruption develops in 10% of users There is cross reactivity with Carbamazepine in 25-30% of cases The risk is highest in Asians The risk alleles are HLA-B*40:02,…
Dermatological side effect: skin eruption
- A maculopapular skin eruption develops in 10% of users
- There is cross reactivity with Carbamazepine in 25-30% of cases
- The risk is highest in Asians
- The risk alleles are HLA-B*40:02, DRB1*04:03, B*15:02, and A*3201
Dermatological side effect: DRESS syndrome: features
Neurological side effects
Hyponatraemia
Genitourinary side effects
Systemic side effects
References
- Shorvon S. Oxcarbazepine: a review. Seizure 2000; 9:75-79.
- Moon J, Kim TJ, Lim JA, et al. HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption. Epilepsia 2016; 57:1879-1886.
- Chen CB, Hsiao YH, Wu T, et al; Taiwan Severe Cutaneous Adverse Reaction Consortium. Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians. Neurology 2017; 88:78-86.
- Xu J, Shi X, Qiu Y, Zhang Y, Chen S, Shi Y, Deng Y. Association between HLA-A*3201 allele and oxcarbazepine-induced cutaneous adverse reactions in Eastern Han Chinese population. Seizure 2019; 65:25-30.
- Bosdure E, Cano A, Roquelaure B, et al. Oxcarbazepine and DRESS syndrome: a paediatric cause of acute liver failure. Arch Pediatr 2004; 11:1073-1077.
- And 16 more. Subscribe to see the full list
