Numb chin syndrome (NCS): causes

Evidence-based neurology checklist on numb chin syndrome (ncs): causes: Malignant causes Leptomeningeal carcinomatosis Mandibular metastases: with compression of the inferior alveolar or mental nerve Skull base metastases: involving the trigeminal nerve root Perineural tumour infiltration of…

Malignant causes

  • Leptomeningeal carcinomatosis
  • Mandibular metastases: with compression of the inferior alveolar or mental nerve
  • Skull base metastases: involving the trigeminal nerve root
  • Perineural tumour infiltration of trigeminal nerve complex

Non-malignant dental causes

Non-malignant medical causes

Non-malignant neurological causes

Frequent primary tumours

Synonyms

References

  1. Arnold AJ, Gilmour GS, Koch MW. Clinical Reasoning: a pregnant woman with chin numbness. Neurology 2019; 92:e996-e999.
  2. Lu SY, Huang SH, Chen YH. Numb chin with mandibular pain or masticatory weakness as indicator for systemic malignancy-a case series study. J Formos Med Assoc 2017; 116:897-906. 
  3. Fusi-Schmidhauser T, Bardelli D. Spontaneous osteonecrosis of the jaw during bisphosphonate therapy: an unusual etiology of the numb chin syndrome. J Pain Palliat Care Pharmacother 2016; 30:206-209.
  4. Zadik Y, Benoliel R, Fleissig Y, Casap N. Painful trigeminal neuropathy induced by oral bisphosphonate-related osteonecrosis of the jaw: a new etiology for the numb-chin syndrome. Quintessence Int 2012; 43:97-104. 
  5. LaBan MM, Wang AM, Chrisman A, Lenger A. "Numb chin" syndrome: mental nerve mononeuropathy resulting from a synovial temporomandibular cyst. Am J Phys Med Rehabil 2015; 94:e65.
  6. And 16 more. Subscribe to see the full list

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