Neurology landmark studies

Evidence-based neurology checklist on neurology landmark studies: Cerebral aneurysms: coiling v clipping Less disability at 1 year (ISAT trial). Molyneux et al, Lancet, 2002 Better independence at 7 years (ISAT trial first follow up). Molyneux et al, Lancet, 2005 Less mortality at 5 years (ISAT…

Cerebral aneurysms: coiling v clipping

  • Less disability at 1 year (ISAT trial). Molyneux et al, Lancet, 2002
  • Better independence at 7 years (ISAT trial first follow up). Molyneux et al, Lancet, 2005
  • Less mortality at 5 years (ISAT trial second follow up). Molyneux et al, Lancet Neurol, 2009
  • Less mortality at 10 years (ISAT trial third follow up). Molyneux et al, Lancet, 2015
  • Nimodipine for post rupture vasospasm. Allen et al, N Engl J Med, 1983

Dementia

Duchenne muscular dystrophy (DMD)

Epilepsy

Guillain Barre syndrome (GBS)

Idiopathic intracranial hypertension (IIH)

Infections

Lambert Eaton myasthenic syndrome (LEMS)

Metabolic

Migraine: anti CGRP antibody drug trials

Migraine: other treatment trials

Motor neurone disease (MND)

Movement disorders

Multiple sclerosis (MS): steroid therapy

Multiple sclerosis (MS): interferon beta 1a drug trials

Multiple sclerosis (MS): interferon beta 1b drug trials

Multiple sclerosis (MS): other disease modifying drug trials

Myasthenia gravis (MG)

Neuroinflammatory

Neuromuscular

Parkinson’s disease (PD)

Prion diseases

Sleep disorders

Spinal muscular atrophy (SMA)

Stroke: clinical

Stroke: secondary prevention

Stroke: management

Stroke: thrombolysis

Stroke: carotid endarterectomy (CEA) and stenting

Stroke: carotid artery stenting v endarterectomy (CEA)

Stroke: thrombectomy

Stroke: embolic from atrial fibrillation: oral anticoagulant trials

Stroke: embolic from unknown source: oral anticoagulant trials

Transient global amnesia (TGA)

Transient epileptic amnesia (TEA)

Trigeminal autonomic cephalalgias (TAC)

Tumours

Vasculopathies

References

  1. Molyneux A, Kerr R, Stratton I, Sandercock P, Clarke M, Shrimpton J, Holman R; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002; 360:1267-1274.
  2. Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005; 366:809-817.
  3. Molyneux AJ, Kerr RS, Birks J, Ramzi N, Yarnold J, Sneade M, Rischmiller J; ISAT Collaborators. Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up. Lancet Neurol 2009; 8:427-433.
  4. Molyneux AJ, Birks J, Clarke A, Sneade M, Kerr RS. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT). Lancet 2015; 385:691-697.
  5. Allen GS, Ahn HS, Preziosi TJ, et al. Cerebral arterial spasm-a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med 1983; 308:619-624.
  6. And 149 more. Subscribe to see the full list

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