Neurological fatigue

Evidence-based neurology checklist on neurological fatigue: Possible pathophysiological mechanisms Proinflammatory cytokines: TNF-alpha, interleukin 1β and interleukin 6 Dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis Impaired astroglial metabolism Reduced noradrenaline and serotonin…

Possible pathophysiological mechanisms

  • Proinflammatory cytokines: TNF-alpha, interleukin 1β and interleukin 6
  • Dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis
  • Impaired astroglial metabolism
  • Reduced noradrenaline and serotonin levels

Central causes

Peripheral causes

Factors that may worsen fatigue

Differential diagnosis

Non-drug treatments

Drug treatments

References

  1. Brola W, Ziomek M, Czernicki J.Fatigue syndrome in chronic neurological disorders. Neurol Neurochir Pol 2007; 41:340-349.
  2. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet 2004; 363:978-988.

Related checklists

Loading...